Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids

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Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids.

Prenatal stress (PS) and maternal exposure to exogenous glucocorticoids can lead to permanent modification of hypothalamo-pituitary-adrenal (HPA) function and stress-related behaviour. Both of these manipulations lead to increased fetal exposure to glucocorticoids. Glucocorticoids are essential for many aspects of normal brain development, but exposure of the fetal brain to an excess of glucoco...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 2006

ISSN: 0022-3751

DOI: 10.1113/jphysiol.2006.105254